CellBIO is a novel biomarker test for cellular oxidative stress in pets using saliva.

What is oxidative stress?

Oxidative stress is the repair process that cells normally undergo after they metabolize oxygen and form free radicals called reactive oxygen species or ROS. However, when ROS production is excessive, cells undergo damage and release biomarker enzymes that lead to tissue ininflammation, infections, obesity and even cancers.

Chronic cellular inflammation

Chronic cellular inflammation from the increased free radical formation of oxidative stress leads to a wide variety of diseases. Chronic inflammation occurs when the tissues or organs receive inflammatory “mediator” messages that cause them to react as though the “trigger” or pathogen was still present.

Rather than repairing themselves, these cells remain in an ongoing state of inflammation that can wax and wane for an entire lifetime. As a result, tissues become deficient in antioxidant mediators, such as malonedialdehyde, glutathione, cysteine, ascorbic acid and other antioxidant vitamins, which is associated with poor clinical outcome. These effects also pertain to the lipid oxidation and risk of rancidity in pet foods with their higher fat and oil content.

Biomarkers of clinical interest in people and pets include isoprostane, NrF2, micro RNA and others. The CellBIO Isoprostane Kit is the first of a set of unique biomarker test for pets measured in dog saliva.

Nutrigenomics for canine health

• The effects of other dietary variables, including functional foods and saturated vs unsaturated fats need to be evaluated
• Older, less healthy animals more likely to exhibit higher levels of disease-related biomarkers. Also more likely to benefit from induction of antioxidant pathways
• New biomarkers, including metabolomic analyses, isoprostanes and miRNAs plus provide earlier assessment of diet-related health effects in younger animals

Holistic care

Holistic medicine equates to humane care that centers on love, empathy and respect. Techniques used are gentle, minimally invasive, and focus on patient well-being and stress reduction. Holistic veterinarians combine the best conventional and alternative, complementary therapies. This natural mixture of healing arts and skills incorporates the environment, nutrition, genetic background, family and social relationships, and disease presentation – and then develops a treatment protocol for healing the patient.

For more information about our Hemopet Holistic Care Veterinary Clinic services, please visit our Hemopet website. Please call 714-494-1175 to schedule a visit to our Hemopet Holistic Care Veterinary Clinic.